ACS Chemical Biology is published by American Chemical Society, DOI: 10.1021/acs.oprd.0c00127, An Economical Route to Lamivudine Featuring a Novel Strategy for Stereospecific Assembly The biosynthetic studies of Idm primarily focused on the formation of the five-membered ring in the tetracyclic structure and the attachment of the methyl group to the core structure. DOI: 10.1021/acs.energyfuels.0c01854, Sample Preparation for Solid Petroleum-Based Matrices Based on Direct Matrix Introduction Oriented to Hydrocarbon Profiling The roles of surrounding membrane lipids in the functions of transmembrane and peripheral membrane proteins are largely unknown. DOI: 10.1021/acsami.0c09139, Solution-Processed Quasi-Two-Dimensional/Nanoscrystals Perovskite Composite Film Enhances the Efficiency and Stability of Perovskite Light-Emitting Diodes DOI: 10.1021/acs.bioconjchem.0c00082, Molecular Imaging for Cancer Immunotherapy: Seeing Is Believing Open Access Through ACS AuthorChoice DOI: 10.1021/acssynbio.9b00172, Synthesizing a Genetic Sensor Based on CRISPR-Cas9 for Specifically Killing p53-Deficient Cancer Cells Open Access Through ACS AuthorChoice Bioconjugate Chem. The journal publishes studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Compared with historical Journal Impact data, the Metric 2019 of ACS Chemical Biology dropped by DOI: 10.1021/acsapm.0c00261, PLGA Barrier Materials from CO2. We found that there are multiple chemically unrelated but physically similar functional groups that can complement any given local protein pocket; when these functional group substitutions are combined within a single molecule, they lead to topologically unrelated ligands that can each well-complement a site. Zika virus is an emerging mosquito-borne pathogen capable of severely damaging developing fetuses as well as causing neurological abnormalities in adults. These results highlight the potential of protease inhibitors to fight bacterial infections and point out the possibility to achieve selective inhibition even with a strong zinc anchor. Open Access through ACS AuthorChoice As controls, we compared the reactivity of these antibodies to two polyclonal anti-SOD1 antibodies expected to be insensitive to misfolding. Open Access through ACS AuthorChoice Open Access through ACS Editors’ Choice Open Access Through ACS AuthorChoice DOI: 10.1021/acssynbio.0c00218, Optogenetic Control of Heterologous Metabolism in E. coli DOI: 10.1021/acsmedchemlett.0c00316, Exploiting Existing Molecular Scaffolds for Long-Term COVID Treatment Results will be published in which molecular reasoning has been used to probe questions through in vitro investigations, cell biological methods, or organismic studies. DOI: 10.1021/acschemneuro.9b00582, Association between Parkinson’s Disease and Risk of Cancer: A PRISMA-compliant Meta-analysis DOI: 10.1021/acsmacrolett.0c00200, Ultrahigh Molecular Weight Hydrophobic Acrylic and Styrenic Polymers through Organic-Phase Photoiniferter-Mediated Polymerization DOI: 10.1021/acs.jpcb.0c04149, Structural Basis of the Potential Binding Mechanism of Remdesivir to SARS-CoV-2 RNA-Dependent RNA Polymerase Open Access Through ACS AuthorChoice Pharmaceutics 2019, 16, 8, 3333–3349 Further investigation in these cells revealed that furamidine treatment at nanomolar concentrations led to up-regulation of MBNL1 and MBNL2 protein levels and a reduction of ribonuclear foci. DOI: 10.1021/acs.biochem.0c00278, Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles 2018, 7, 7, 1798–1807 Open Access through ACS AuthorChoice 2020, 3, 1, 148–160 DOI: 10.1021/acs.cgd.0c00635, Emerging Strategies for Developing High-Performance Perovskite-Based Materials for Electrochemical Water Splitting Nicotinamide-N-methyltransferase (NNMT) catalyzes the irreversible methylation of nicotinamide (NAM) to form N-methyl nicotinamide using S-adenosyl methionine as a methyl donor. Nano Lett. DOI: 10.1021/acs.est.0c01009, Update to Our Reader, Reviewer, and Author Communities—April 2020 Marine Sponge Collected in Southern Australia Open Access Through ACS AuthorChoice Open Access Through ACS AuthorChoice DOI: 10.1021/acs.energyfuels.0c02068, Confronting Racism in Chemistry Journals DOI: 10.1021/acs.jctc.0c00246, COVID-19: Drug Targets and Potential Treatments DOI: 10.1021/acs.jpca.0c01513, Update to Our Reader, Reviewer, and Author Communities—April 2020 Journal Impact Prediction System provides an open, transparent, and straightforward platform to help academic researchers Predict future Metric and performance through the wisdom of crowds. Anyone who wants to read the articles should pay by individual or institution to access the articles. DOI: 10.1021/acs.biochem.0c00307, Welcome New Executive Editor, Bryan Roth ACS Biomaterials Science & Engineering publishes high-quality research in the field of biomaterials science & engineering. Open Access through ACS AuthorChoice Manuscripts can be submitted for consideration by choosing “chemical glycobiology” from the special issue dropdown menu in Paragon Plus during the submission process to ACS Chemical Biology. DOI: 10.1021/acscombsci.0c00001, Ce(OTf)3-Catalyzed Multicomponent Reaction of Alkynyl Carboxylic Acids, tert-Butyl Isocyanide, and Azides for the Assembly of Triazole–Oxazole Derivatives Open Access Through ACS AuthorChoice The mutations cause misfolding and self-assembly of SOD1 into toxic oligomers and aggregates, resulting in motor neuron degeneration. 2020, 6, 4, 1852–1873 The approaches applied here highlight the steps at which the choice of E3 ligase handle can elicit different outcomes and discern individual parameters required for degradation, ultimately enabling chemical design strategies and rank ordering of potential therapeutic compounds. Open Access Through ACS AuthorChoice Open Access Through ACS AuthorChoice The former of these is attached through a canonical O-glycosidic linkage, but the latter is connected via an unusual dual linkage composed of C–C and O-glycosidic bonds. Blood, This journal is dedicated to understanding the molecular basis of neurological function in all organisms and model systems. DOI: 10.1021/acschembio.0c00429 ACS Chemical Biology provides an international forum for the rapid communication of research that broadly embraces the interface between chemistry and biology. DOI: 10.1021/acs.joc.0c00882, Characteristics of Impactful Computational Contributions to The Journal of Physical Chemistry A Open Access Through ACS AuthorChoice DOI: 10.1021/acs.jced.0c00397, Reply to the “Comment on ‘Study on Phase Equilibrium of the K+, Mg2+//Cl–, SO42– + H2O Quaternary System at 353.15 K and Its Application’” Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics DOI: 10.1021/acscatal.0c01209, Light-Mediated Asymmetric Aliphatic C–H Alkylation with Hydrogen Atom Transfer Catalyst and Chiral Phosphoric Acid Get article recommendations from ACS based on references in your Mendeley library. DOI: 10.1021/acs.energyfuels.0c01997, Stability, Combustion, and Compatibility of High-Viscosity Heavy Fuel Oil Blends with a Fast Pyrolysis Bio-Oil Note: The impact factor shown here is equivalent to citescore and is, therefore, used as a replacement for the same. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Open Access Through ACS AuthorChoice DOI: 10.1021/acs.biochem.0c00275, Parsing Molecules for Drug Discovery Open Access Through ACS AuthorChoice DOI: 10.1021/jasms.9b00149, Update to Our Reader, Reviewer, and Author Communities—April 2020 Graphene-Induced Transdifferentiation of Cancer Stem Cells as a Therapeutic Strategy against Glioblastoma These data are consistent with the following. DOI: 10.1021/acssynbio.0c00149, Pattern Engineering of Living Bacterial Colonies Using Meniscus-Driven Fluidic Channels DOI: 10.1021/jasms.0c00230, Science Moves Forward When We Work Together DOI: 10.1021/acs.nanolett.0c01230, A Carry-On Nitric-Oxide-Luggage for Enhanced Chemotherapeutic Efficacy Despite the emerging prominence of RhlR in QS pathways, there has been limited exploration of the chemical features of the BHL scaffold that are critical to its function. DOI: 10.1021/acs.organomet.0c00218, Pioneers and Influencers in Organometallic Chemistry: Professor Yao-Zeng Huang and His Three “Treasure Chests” DOI: 10.1021/acs.molpharmaceut.0c00504, Injectable Anti-inflammatory Nanofiber Hydrogel to Achieve Systemic Immunotherapy Post Local Administration ACS Chem. DOI: 10.1021/acs.langmuir.0c01832, PLL–Poly(HPMA) Bottlebrush-Based Antifouling Coatings: Three Grafting Routes DOI: 10.1021/acs.jced.0c00536, Measurement and Correlation of Solubility and Thermodynamic Properties of Fluoxetine Hydrochloride in 15 Pure Solvents and a Methanol + Water Binary Solvent System

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