Research Collaboratory for Structural Bioinformatics: Carbonic Anhydrase, The European Bioinformatics Institute: Carbonic Anhydrase, Map of Life: Carbonic Anhydrase in Vertebrates, Plants, Algae, and Bacteria, Mayo Clinic: Carbonic Anhydrase Inhibitor (Oral Route, Parenteral Route), Current Pharmaceutical Design: Cancer-Associated Carbonic Anhydrases and Their Inhibition, Plant, Cell, and Environment: Carbonic Anhydrase in Plants and Algae, Anticancer Agents Med Chem: Inhibition of Carbonic Anhydrase IX: a New Strategy Against Cancer. CA inhibition has therapeutic applications for drugs acting as diuretics, antiepileptics, antiglaucoma, antiobesity and antitumour agents. Function Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Curr Pharm Des. As more and more carbon dioxide is released and then removed from the atmosphere, the ocean becomes more acidic, having potential damaging effects for marine life. Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle. Bioorg Med Chem. Theparambil SM, Hosford PS, Ruminot I, Kopach O, Reynolds JR, Sandoval PY, Rusakov DA, Barros LF, Gourine AV. possessing the general formula RXSO(2)NH(2) (R = aryl; hetaryl; perhaloalkyl; X = nothing, O or NH). 2007 Jul 1;15(13):4336-50. doi: 10.1016/j.bmc.2007.04.020. Get the latest research from NIH: 2020 Jun 5;15(1):208. doi: 10.1186/s13018-020-01735-1. COVID-19 is an emerging, rapidly evolving situation. This site needs JavaScript to work properly. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: 527, No. Soydan E, Olcay AC, Bilir G, Taş Ö, Şentürk M, Ekinci D, Supuran CT. J Enzyme Inhib Med Chem. Future Med Chem. The CA activation and inhibition mechanisms are also known in detail, with a large number of new inhibitor classes being described in the last years. At least 25 clinically used drugs/agents in clinical development show applications as diuretics and antiglaucoma drugs, anticonvulsants, with some compounds being developed as anticancer agents/diagnostic tools for tumors, antiobesity agents, and antimicrobials/antifungals (inhibitors targeting CAs from pathogenic organisms such as Helicobacter pylori, Mycobacterium tuberculosis, Plasmodium falciparum, Candida albicans, etc). In Silico Identification and Biological Evaluation of Antioxidant Food Components Endowed with IX and XII. Nocentini A, Cuffaro D, Ciccone L, Orlandini E, Nencetti S, Nuti E, Rossello A, Supuran CT. J Enzyme Inhib Med Chem. Epub 2014 Apr 25. 2020 Dec;35(1):1891-1905. doi: 10.1080/14756366.2020.1828401. Epub 2007 Apr 19. carbonic anhydrase an enzyme that catalyzes the decomposition of carbonic acid into carbon dioxide and water, facilitating transfer of carbon dioxide from tissues to blood and from blood to alveolar air. 2020 Oct 8;11(1):5073. doi: 10.1038/s41467-020-18756-3. One difference is that plant cells obtain carbon dioxide from air and soil instead of producing it. Scott has a biochemistry degree from UCSB with research experience and has a passion for science as well as writing. The plant version is found in the liquid part of the cell, while the animal version is found in cell mitochondria. Carbonic anhydrase is a crucial enzyme that operates in animal cells, plant cells, and in the environment to stabilize carbon dioxide concentrations. Bioorg Med Chem. NLM Get the latest public health information from CDC:

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