In case of a triplet pregnancy, a good oby/gyn remains the golden standard. We had our anatomy scan over a week ago. The main question pertains to the NIPT performance in dizygotic twins. NIPT primarily looks for Down syndrome (trisomy 21, caused by an extra chromosome 21 ), trisomy 18 (caused by an extra chromosome 18 ), trisomy 13 (caused by an extra chromosome 13 ), and extra or missing copies of the X chromosome and Y chromosome (the sex chromosomes). I know it's not the same at all, but the families who have been down the same path as you really are an amazing resource. Current estimates indicate the twinning frequency in the US to be about one every 30 pregnancies. NIPT is more accurate than the traditional first-trimester blood screenings (such as blood work or quad screening). While NIPT is mainly aimed for the detection of trisomy 21, other chromosomal anomalies and especially the risks for the presence of a fetal trisomy 13 and 18 are also reported. She's all smiles, loves cuddles and is about the size of a 1.5yr old. The screen‐positive rate, with 95% CIs, of fetuses with abnormal or normal karyotype on screening with the previously reported algorithm 1 is shown in Table 2.At a risk cut‐off of 1 in 100 for trisomy 21, 18 or 13, at the gestational age of screening, the observed FPR was 4.6% and the DR was 92%, 96% and 93% for trisomies 21, 18 and 13, respectively. Trisomy 18 (Edwards syndrome) Trisomy 13 (Patau syndrome) Common sex chromosome conditions, such as Klinefelter syndrome and Turner syndrome ; Some labs may screen for a few other conditions as well, if you choose. Because first trimester screening can be done earlier than most other prenatal screening tests, you'll have the results early in your pregnancy. Only a cvs or amnio can confirm if your baby has trisomy 18. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. We keep them up because there are a ton of great conversations here and we believe you deserve to see them all. The testing is now done in Australia and results are available in about ten days. It is just heart breaking. The incidence of trisomy 13 and 18 is only half of the incidence of chromosome 21. Welcome to the news page. The test can also test for Rh blood type. For singleton pregnancies test accuracies are widely reported by test providers and are the core of the validation studies with sensitivities and specificities over 98%. We are finding it so hard to believe as we have no indications at all on ultrasound. NIPT positive for trisomy21- HELP: Hi all I have already posted here regarding risk in NT SCAN and combined blood tests. It was absolutely heart breaking, but she now has a beautiful, happy, healthy almost-1-year-old little girl. Test results. We can distinguish dizygotic twins, twins derived from two zygotes versus monozygotic twins originating from a single zygote that split during the very early cleavage divisions. The test is 90 to 99% accurate with false positive rates of less than 1%. Hey ladies so Im 13 weeks and 5 days pregnant and I just got the results back from my first trimester prenatal screening. I was as well devastated all I could think was what more can happen to me. Archived discussions are usually a bit older and not as active as other community content. I recommend looking to them to help you through this difficult time. Of course, NIPT is only one of the methods of care during a pregnancy. This action cannot be undone. We respect everyone’s right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expect’s Terms of Use. Longest and hardest 3 weeks of my life!!! The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. The NIPT measures the fetal cfDNA in the mother’s bloodstream, which comes from the placenta. A message from the editor: Prof. Joris Vermeesch, Ph.D. Twinning is quite frequent. Doctor, what is my problem? Are you sure you want to delete your comment? Has anyone else gone through this and become pregnant again? With increasing adoption of NIPT we will obtain better insights about the success rates as well as the accuracies, not only for trisomy 21 detection but also for trisomy 13 and 18. NIPT is neither negative nor positive, there is no result! As a consequence, the number of twin cases with trisomies 18 and 13 reported is thus too small for accurate assessment of the predictive performance of the cfDNA test. She ended up passing around 24 weeks gestation. We are 12w4d and received a positive result for trisomy 18. NIPT is more than 99% accurate (with a 0.2% false positive rate), while CFTS is only around 90% accurate (with a 5% false positive rate). We strive to provide you with a high quality community experience. Are you sure you want to delete your discussion? They really helped me when I got my daughter's diagnosis (T21 at 16 weeks). The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. 3 total healthy babies. Triplet pregnancies are more exceptional with an incidence of 1 to 2 in 10000 live births. First trimester screening doesn't evaluate the risk of neural tube defects, such as spina bifida. As a conclusion, I would say that the stars are properly aligned to assure that twin NIPT is acceptable. While all non-invasive prenatal test providers are vocally about the high sensitivities and specificities of their tests, much less information is provided about the frequency tests fail to provide a... A message from the editor: Prof. Joris Vermeesch, Ph.D. Twinning is quite frequent. This discussion is archived and locked for posting. Apparently I have a high risk of Trisomy 18 so My doctor scheduled me for a NIPT so they can get more accurate results... Hello! What to Expect has thousands of open discussions happening each day. At my 20 blood work I tested positive for baby girl to have T18 as well. Today I received a phone call from the doctor’s office that said they saw everything they wanted to see, but never said everything looked good. Use of this site is subject to our terms of use and privacy policy. Make sure you check with the test provider which information is available. With that being said my FF (fetal fraction) was 2.6%, too low to test, through... Find advice, support, and good company (and some stuff just for fun). “With CFTS, we have to do about 20 amniocenteses for every … This test screens for: Trisomy 21 (Down syndrome) - 99.5% accurate; Trisomy 18 (Edwards syndrome) - 97% accurate; Trisomy 13 (Patau syndrome) - 94% accurate

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